Regulatory Mechanisms of Human Ige Synthesis

Genetic regulatory mechanisms in the synthesis of proteins.

Francois Jacob Born 1920 in Nancy, France. Completed M.D. degree (1947) at Faculty of Paris, and a obtained doctorate in Science (1954) at the Sorbonne. Joined Institute Pasteur as research assistant (1950), under Dr. André Lwoff. Appointed Laboratory Director (1956) and Head of Dept. of Cell Genetics (1960). Began collaboration with Monod (1958) at Institute Pasteur. In 1964 became a Professor...

Regulatory Mechanisms Controlling Inflammation and Synthesis of Acute Phase Proteins

Twenty years with IgE: from the identification of IgE to regulatory factors for the IgE response.

Omalizumab may decrease IgE synthesis by targeting membrane IgE+ human B cells

BACKGROUND Omalizumab, is a humanized anti-IgE monoclonal antibody used to treat allergic asthma. Decreased serum IgE levels, lower eosinophil and B cell counts have been noted as a result of treatment. In vitro studies and animal models support the hypothesis that omalizumab inhibits IgE synthesis by B cells and causes elimination of IgE-expressing cells either by induction of apoptosis or ind...

Molecular Mechanisms of IgE Class Switch Recombination.

Immunoglobulin (Ig) E is the most tightly regulated of all Ig heavy chain (IgH) isotypes and plays a key role in atopic disease. The gene encoding for IgH in mature B cells consists of a variable region exon-assembled from component gene segments via V(D)J recombination during early B cell development-upstream of a set of IgH constant region CH exons. Upon activation by antigen in peripheral ly...